← pool

📈 FDA's loosened approval bar creates markets — capital floods the biotech complex

The Aduhelm approval over a unanimous negative advisory vote is read as deliberate market-creation: with a defensible safety study now the effective bar, the FDA conjures multi-billion-dollar indications out of nothing, and startups plus incumbents rush the newly defined markets. The beneficiary is the emerging-biotech complex, not just Biogen.

0 CONVICTION
peaked 65.2 GREEN
DORMANT
band · contested
▲ LONG XBI
expression · bullish equities
WRONG
result · return -53.7% · vs SPY -43.0%
2022-06-13
born 2021-06-13 (E35) → window closed

⚖ Why this result

fully deterministic — computed from daily closes on the scoring date; nothing below is editable or hand-set

  1. Window: 2021-06-13 → 2022-06-13 — first mention + 12-month horizon, then the window locks.
  2. The call: ▲ LONG XBI (primary play). XBI fell 53.7% over the window → return (sign flipped for a SHORT) = -53.7% (the call lost money).
  3. Benchmark: holding SPY over the same window returned -10.7% → vs SPY = -53.7 − (-10.7) = -43.0% — what this call made or lost against just owning the index. This is the number the result uses.
  4. Rule fired:
    · RIGHT — return ≥ +10% AND beat SPY by 5+
    · HALF — return ≥ +5% OR beat SPY at all
    ▶ WRONG — everything else
  5. Credit: supporters of a WRONG earn 0 each, opposers the opposite — this feeds the scoreboard. supported: Chamath, Sacks | opposed: Friedberg

Conviction timeline

bands: green ≥ 65 · watch ≥ 45 · ember ≥ 15

Plays vs SPY · % since first mention (2021-06-13)

Plays

expressionsymbolkindrelevancerationale
▲ LONG XBIetf PRIMARY equal-weight emerging biotech — the direct expression of 'a lot of young startups will say I should be going after this market'
▲ LONG BIIBstock adjacent the approval's direct beneficiary; added ~$20B of market cap in the five days after
▲ LONG IBBetf adjacent large-cap-weighted biotech complex proxy for a looser approval regime

Mention log newest first

Friedberg
Friedberg equities 43% · n=123 · E80 (2022-05-13) · explicit_prediction · strength 2 ▶ 29:08 REVERSAL
“roughly one third of public biotech stocks are trading below cash. ... But because the capital markets are gone now for them, or the assumption is, hey, there's not going to be any capital left”
Friedberg
Friedberg equities 43% · n=123 · E59 (2021-12-17) · explicit_prediction · strength 2 ▶ 1:09:02 SUPPORT
“they really kind of struggled for years to find the right footing of what's the right business model and the right product and the FDA kind of struggled with approving this stuff. And then boom, COVID hit. ... I think there's now a few, a handful of these RNA interference products that have been approved by the FDA. And we're now starting to see many more of these cancer and immunotherapy drugs start to get approved as RNA therapies.”
Friedberg
Friedberg equities 43% · n=123 · E35 (2021-06-13) · explicit_prediction · strength 2 ▶ 23:27 SUPPORT · horizon 24mo
“Companies are going to rush in, they're going to try and get 10 things approved. Everyone's going to be taking an Alzheimer's drug in a couple of years because there's going to be so many available on the market. And none of them may actually be curing Alzheimer's.”
Chamath
Chamath equities 42% · n=163 · E35 (2021-06-13) · explicit_prediction · strength 3 ▶ 20:55 SUPPORT
“they applied an extremely aggressive free market approach to a market that has been completely bereft of solutions. ... And so if you can create a hundred billion dollar market overnight, I think it stands to reason that a lot of people will look at the increase in Biogen's market cap and the profits that Biogen can make over the next 10 or 15 years and say, I will attack that and do that cheaper, faster, better. It happens in every other market.”
Sacks
Sacks equities 44% · n=96 · E35 (2021-06-13) · sentiment · strength 2 ▶ 17:08 SUPPORT
“But going to the sort of larger issue of FDA approval, I would make it a little bit easier to get drugs approved. I mean, look, I think that double-blind test is the gold standard. If the drug clearly doesn't work, you don't approve it. But this is a case where the evidence is a little bit inconclusive.”

Who built this conviction

each voice's total push on the score, in conviction points across every mention — supports and opposes · share = % of all mention-driven movement

Chamath
Chamath 42%
1 scoring event · 49% of moves
+42.0 → net +42.0
Friedberg
Friedberg 43%
3 scoring events · 36% of moves
+21.1 / -10.4 → net +10.8
Sacks
Sacks 44%
1 scoring event · 15% of moves
+13.1 → net +13.1

⏳ decay drained -59.4 over the idea's life — that's time passing, attributed to no one

Score events

episodekindΔafternote
E35 2021-06-13 init +42.0 42.0 E35 born by Chamath (explicit_prediction x3)
E35 2021-06-13 reinforce +13.1 55.0 E35 Sacks support x2 (new voice)
E35 2021-06-13 reinforce +10.1 65.2 E35 Friedberg support x2 (new voice)
E36 2021-06-18 decay -2.6 62.6 E36 silent
E37 2021-06-25 decay -2.5 60.1 E37 silent
E38 2021-07-03 decay -2.4 57.7 E38 silent
E39 2021-07-09 decay -2.3 55.3 E39 silent
E40 2021-07-16 decay -2.2 53.1 E40 silent
E41 2021-07-23 decay -2.1 51.0 E41 silent
E42 2021-07-30 decay -2.0 49.0 E42 silent
E43 2021-08-06 decay -2.0 47.0 E43 silent
E44 2021-08-28 decay -1.9 45.1 E44 silent
E45 2021-09-04 decay -1.8 43.3 E45 silent
E46 2021-09-14 decay -1.7 41.6 E46 silent
E47 2021-09-18 decay -1.7 39.9 E47 silent
E49 2021-10-02 decay -1.6 38.3 E49 silent
E50 2021-10-09 decay -1.5 36.8 E50 silent
E51 2021-10-16 decay -1.5 35.3 E51 silent
E52 2021-10-23 decay -1.4 33.9 E52 silent
E53 2021-10-30 decay -1.4 32.6 E53 silent
E54 2021-11-06 decay -1.3 31.3 E54 silent
E55 2021-11-13 decay -1.3 30.0 E55 silent
E56 2021-11-20 decay -1.2 28.8 E56 silent
E57 2021-12-04 decay -1.2 27.7 E57 silent
E58 2021-12-11 decay -1.1 26.5 E58 silent
E59 2021-12-17 reinforce +11.0 37.6 E59 Friedberg support x2
E60 2021-12-23 decay -1.5 36.1 E60 silent
E61 2021-12-29 decay -1.4 34.6 E61 silent
E62 2022-01-08 decay -1.4 33.2 E62 silent
E63 2022-01-15 decay -1.3 31.9 E63 silent
E64 2022-01-22 decay -1.3 30.6 E64 silent
E65 2022-01-29 decay -1.2 29.4 E65 silent
E66 2022-02-05 decay -1.2 28.2 E66 silent
E67 2022-02-12 decay -1.1 27.1 E67 silent
E68 2022-02-19 decay -1.1 26.0 E68 silent
E70 2022-02-24 decay -1.0 25.0 E70 silent
E71 2022-03-05 decay -1.0 24.0 E71 silent
E72 2022-03-19 decay -1.0 23.0 E72 silent
E73 2022-03-26 decay -0.9 22.1 E73 silent
E74 2022-04-01 decay -0.9 21.2 E74 silent
E75 2022-04-09 decay -0.8 20.4 E75 silent
E76 2022-04-16 decay -0.8 19.5 E76 silent
E77 2022-04-23 decay -0.8 18.8 E77 silent
E78 2022-04-30 decay -0.8 18.0 E78 silent
E79 2022-05-07 decay -0.7 17.3 E79 silent
E80 2022-05-13 reversal -10.4 6.9 E80 Friedberg flips
E81 2022-05-23 decay -0.3 6.6 E81 silent
E82 2022-05-24 decay -0.3 6.4 E82 silent